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Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics
Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China
Biomedical Group, Nitto Denko Technical Corporation, 501 Via Del Monte, Oceanside, CA 92058, USA
* Author to whom correspondence should be addressed.
Received: 12 November 2010; in revised form: 10 December 2010 / Accepted: 22 December 2010 / Published: 23 December 2010
Abstract: The concept of utilizing polymers in drug delivery has been extensively explored for improving the therapeutic index of small molecule drugs. In general, polymers can be used as polymer-drug conjugates or polymeric micelles. Each unique application mandates its own chemistry and controlled release of active drugs. Each polymer exhibits its own intrinsic issues providing the advantage of flexibility. However, none have as yet been approved by the U.S. Food and Drug Administration. General aspects of polymer and nano-particle therapeutics have been reviewed. Here we focus this review on specific clinically relevant anticancer polymer paclitaxel therapeutics. We emphasize their chemistry and formulation, in vitro activity on some human cancer cell lines, plasma pharmacokinetics and tumor accumulation, in vivo efficacy, and clinical outcomes. Furthermore, we include a short review of our recent developments of a novel poly(L-g-glutamylglutamine)-paclitaxel nano-conjugate (PGG-PTX). PGG-PTX has its own unique property of forming nano-particles. It has also been shown to possess a favorable profile of pharmacokinetics and to exhibit efficacious potency. This review might shed light on designing new and better polymer paclitaxel therapeutics for potential anticancer applications in the clinic.
Keywords: polymer paclitaxel therapeutics; polymeric micelles; polymer paclitaxel conjugates
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Cite This Article
MDPI and ACS Style
Yang, D.; Yu, L.; Van, S. Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics. Cancers 2011, 3, 17-42.
Yang D, Yu L, Van S. Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics. Cancers. 2011; 3(1):17-42.
Yang, Danbo; Yu, Lei; Van, Sang. 2011. "Clinically Relevant Anticancer Polymer Paclitaxel Therapeutics." Cancers 3, no. 1: 17-42.