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Cancers 2011, 3(1), 1-16; doi:10.3390/cancers3010001
Review
The Role of Apoptosis in the Pathology of Pancreatic Cancer
Nicole Samm
, Kristin Werner, Felix Rückert, Hans Detlev Saeger, Robert Grützmann and Christian Pilarsky*
, Kristin Werner, Felix Rückert, Hans Detlev Saeger, Robert Grützmann and Christian Pilarsky*
Department of Visceral-, Thoracic- and Vascular-Surgery, University Hospital Dresden, Dresden, Germany
* Author to whom correspondence should be addressed.
Received: 11 November 2010; in revised form: 14 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
(This article belongs to the Special Issue Pancreatic Cancer)
Download PDF Full-Text [494 KB, uploaded 23 December 2010 11:23 CET]
Abstract: Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer.
Keywords: apoptosis; signal transduction pathway; pancreatic cancer
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MDPI and ACS Style
Samm, N.; Werner, K.; Rückert, F.; Saeger, H.D.; Grützmann, R.; Pilarsky, C. The Role of Apoptosis in the Pathology of Pancreatic Cancer. Cancers 2011, 3, 1-16.
AMA StyleSamm N, Werner K, Rückert F, Saeger HD, Grützmann R, Pilarsky C. The Role of Apoptosis in the Pathology of Pancreatic Cancer. Cancers. 2011; 3(1):1-16.
Chicago/Turabian StyleSamm, Nicole; Werner, Kristin; Rückert, Felix; Saeger, Hans Detlev; Grützmann, Robert; Pilarsky, Christian. 2011. "The Role of Apoptosis in the Pathology of Pancreatic Cancer." Cancers 3, no. 1: 1-16.