The Role of Apoptosis in the Pathology of Pancreatic Cancer
AbstractPancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Samm, N.; Werner, K.; Rückert, F.; Saeger, H.D.; Grützmann, R.; Pilarsky, C. The Role of Apoptosis in the Pathology of Pancreatic Cancer. Cancers 2011, 3, 1-16.
Samm N, Werner K, Rückert F, Saeger HD, Grützmann R, Pilarsky C. The Role of Apoptosis in the Pathology of Pancreatic Cancer. Cancers. 2011; 3(1):1-16.Chicago/Turabian Style
Samm, Nicole; Werner, Kristin; Rückert, Felix; Saeger, Hans Detlev; Grützmann, Robert; Pilarsky, Christian. 2011. "The Role of Apoptosis in the Pathology of Pancreatic Cancer." Cancers 3, no. 1: 1-16.