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Neural Invasion in Pancreatic Cancer: The Past, Present and Future
Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
* Author to whom correspondence should be addressed.
Received: 2 June 2010; in revised form: 30 June 2010 / Accepted: 7 July 2010 / Published: 14 July 2010
Abstract: In the past 15 years, invasion of nerves by cancer cells has escaped from its role as a mere bystander in cancer biology and turned into an attractive niche to study the heterotypic interaction between cancer cells and neurons. Today, neural invasion (NI) in pancreatic cancer (PCa) stands out due to the recent demonstration of its association with tumor progression, local recurrence and neuropathic pain. Accordingly, recent research on NI in PCa revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in several novel in vitro and in vivo models of NI, which, however, still need further major improvement.
Keywords: neural invasion; neurotrophic factors; pancreatic neuropathy; neuroplasticity; neurotropism
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MDPI and ACS Style
Demir, I.E.; Ceyhan, G.O.; Liebl, F.; D’Haese, J.G.; Maak, M.; Friess, H. Neural Invasion in Pancreatic Cancer: The Past, Present and Future. Cancers 2010, 2, 1513-1527.
Demir IE, Ceyhan GO, Liebl F, D’Haese JG, Maak M, Friess H. Neural Invasion in Pancreatic Cancer: The Past, Present and Future. Cancers. 2010; 2(3):1513-1527.
Demir, Ihsan Ekin; Ceyhan, Güralp O.; Liebl, Florian; D’Haese, Jan G.; Maak, Matthias; Friess, Helmut. 2010. "Neural Invasion in Pancreatic Cancer: The Past, Present and Future." Cancers 2, no. 3: 1513-1527.