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Cancers 2010, 2(3), 1513-1527; doi:10.3390/cancers2031513

Neural Invasion in Pancreatic Cancer: The Past, Present and Future

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
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Received: 2 June 2010 / Revised: 30 June 2010 / Accepted: 7 July 2010 / Published: 14 July 2010
(This article belongs to the Special Issue Pancreatic Cancer)
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Abstract

In the past 15 years, invasion of nerves by cancer cells has escaped from its role as a mere bystander in cancer biology and turned into an attractive niche to study the heterotypic interaction between cancer cells and neurons. Today, neural invasion (NI) in pancreatic cancer (PCa) stands out due to the recent demonstration of its association with tumor progression, local recurrence and neuropathic pain. Accordingly, recent research on NI in PCa revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in several novel in vitro and in vivo models of NI, which, however, still need further major improvement.
Keywords: neural invasion; neurotrophic factors; pancreatic neuropathy; neuroplasticity; neurotropism neural invasion; neurotrophic factors; pancreatic neuropathy; neuroplasticity; neurotropism
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Demir, I.E.; Ceyhan, G.O.; Liebl, F.; D’Haese, J.G.; Maak, M.; Friess, H. Neural Invasion in Pancreatic Cancer: The Past, Present and Future. Cancers 2010, 2, 1513-1527.

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