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Cancers 2010, 2(2), 653-669; doi:10.3390/cancers2020653

MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)

Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University/1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan
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Received: 5 March 2010 / Revised: 2 April 2010 / Accepted: 15 April 2010 / Published: 21 April 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs which regulate cell differentiation, proliferation, development, cell cycle, and apoptosis. Expression profiling of miRNAs has been performed and the data show that some miRNAs are upregulated or downregulated in cancer. Several studies suggest that the expression profiles of miRNAs are associated with clinical outcomes. However, the set of miRNAs with altered expressing differs depending on the type of cancer, suggesting that it is important to understand which miRNAs are related to which cancers. Therefore, this review aimed to discuss potentially crucial miRNAs in head and neck squamous cell carcinoma (HNSCC) and oral squamous cell carcinoma (OSCC).
Keywords: microRNA; head and neck squamous cell carcinoma; oral squamous cell carcinoma microRNA; head and neck squamous cell carcinoma; oral squamous cell carcinoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shiiba, M.; Uzawa, K.; Tanzawa, H. MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC). Cancers 2010, 2, 653-669.

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