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Cancers 2010, 2(2), 670-692; doi:10.3390/cancers2020670
Review

Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis?

Received: 10 March 2010; in revised form: 19 April 2010 / Accepted: 22 April 2010 / Published: 26 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Abstract: There is documented evidence of significant associations between cancer of the lung, kidney, pancreas, hematological and oral cancers and periodontal diseases of the supporting structures of the teeth. Enhanced lipid peroxidation, raised levels of TBARS and the oxidative stress marker malondealdehyde have been detected in breast cancer with reduced antioxidant capacity, also characteristic of periodontal diseases. Antioxidants could overcome this deficit and attenuate disease progression by down regulating glutathione detoxification/redox buffering system and inhibiting key transcription factors. Periodontal disease may be a critical marker of a susceptible immune system, or initiate cancer risk with a pro-oxidant inflammatory profile.
Keywords: oxidative stress; cancer; periodontal disease; inflammatory profile; antioxidants oxidative stress; cancer; periodontal disease; inflammatory profile; antioxidants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Soory, M. Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis? Cancers 2010, 2, 670-692.

AMA Style

Soory M. Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis? Cancers. 2010; 2(2):670-692.

Chicago/Turabian Style

Soory, Mena. 2010. "Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis?" Cancers 2, no. 2: 670-692.



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