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Cancers 2010, 2(2), 670-692; doi:10.3390/cancers2020670

Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis?

Periodontology, King’s College London Dental Institute, Denmark Hill, London SE5 9RW, UK
Received: 10 March 2010 / Revised: 19 April 2010 / Accepted: 22 April 2010 / Published: 26 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
View Full-Text   |   Download PDF [488 KB, uploaded 26 April 2010]   |  

Abstract

There is documented evidence of significant associations between cancer of the lung, kidney, pancreas, hematological and oral cancers and periodontal diseases of the supporting structures of the teeth. Enhanced lipid peroxidation, raised levels of TBARS and the oxidative stress marker malondealdehyde have been detected in breast cancer with reduced antioxidant capacity, also characteristic of periodontal diseases. Antioxidants could overcome this deficit and attenuate disease progression by down regulating glutathione detoxification/redox buffering system and inhibiting key transcription factors. Periodontal disease may be a critical marker of a susceptible immune system, or initiate cancer risk with a pro-oxidant inflammatory profile. View Full-Text
Keywords: oxidative stress; cancer; periodontal disease; inflammatory profile; antioxidants oxidative stress; cancer; periodontal disease; inflammatory profile; antioxidants
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Soory, M. Oxidative Stress Induced Mechanisms in the Progression of Periodontal Diseases and Cancer: A Common Approach to Redox Homeostasis? Cancers 2010, 2, 670-692.

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