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Cancers 2010, 2(2), 513-522; doi:10.3390/cancers2020513

Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women

Folkhälsan Research Center, Institute for Preventive Medicine, Nutrition and Cancer, and Division of Clinical Chemistry, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014, Finland
Author to whom correspondence should be addressed.
Received: 9 April 2010 / Revised: 12 April 2010 / Accepted: 12 April 2010 / Published: 14 April 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Alkylresorcinols [ARs] have been proposed for use as biomarkers of whole-grain intake. The aim here was to examine the responsiveness of AR metabolites to rye intake. Sixty women were divided into three groups according to their rye consumption. We observed significant differences between groups in plasma 3-[3,5-dihydroxyphenyl]-1-propanoic acid [DHPPA] and in urinary DHPPA and 3,5-dihydroxybenzoic acid [DHBA]. In addition, these AR metabolites increased proportionally to rye fiber intake. We conclude that these ARs metabolites are accurate and useful biomarkers of rye fiber intake. Further studies are needed to confirm our results in larger and different populations.
Keywords: whole-grain cereals; rye; alkylresorcinol metabolites; responsiveness whole-grain cereals; rye; alkylresorcinol metabolites; responsiveness
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aubertin-Leheudre, M.; Koskela, A.; Samaletdin, A.; Adlercreutz, H. Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women. Cancers 2010, 2, 513-522.

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