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Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del giochetto, 06124 Perugia, Italy
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Received: 26 February 2010; in revised form: 18 March 2010 / Accepted: 12 April 2010 / Published: 13 April 2010
Abstract: Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
Keywords: oxidative stress; chemoprevention; chemotherapy
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Bellezza, I.; Mierla, A.L.; Minelli, A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2010, 2, 483-497.
Bellezza I, Mierla AL, Minelli A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers. 2010; 2(2):483-497.
Bellezza, Ilaria; Mierla, Anna Lisa; Minelli, Alba. 2010. "Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression." Cancers 2, no. 2: 483-497.