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The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics
Cancers 2010, 2(2), 483-497; doi:10.3390/cancers2020483

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

* ,
Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del giochetto, 06124 Perugia, Italy
* Author to whom correspondence should be addressed.
Received: 26 February 2010 / Revised: 18 March 2010 / Accepted: 12 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
Keywords: oxidative stress; chemoprevention; chemotherapy oxidative stress; chemoprevention; chemotherapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bellezza, I.; Mierla, A.L.; Minelli, A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2010, 2, 483-497.

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