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The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics
Cancers 2010, 2(2), 483-497; doi:10.3390/cancers2020483
Review

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

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Received: 26 February 2010; in revised form: 18 March 2010 / Accepted: 12 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Abstract: Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
Keywords: oxidative stress; chemoprevention; chemotherapy oxidative stress; chemoprevention; chemotherapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bellezza, I.; Mierla, A.L.; Minelli, A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2010, 2, 483-497.

AMA Style

Bellezza I, Mierla AL, Minelli A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers. 2010; 2(2):483-497.

Chicago/Turabian Style

Bellezza, Ilaria; Mierla, Anna Lisa; Minelli, Alba. 2010. "Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression." Cancers 2, no. 2: 483-497.


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