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Cancers 2010, 2(2), 483-497; doi:10.3390/cancers2020483

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del giochetto, 06124 Perugia, Italy
Author to whom correspondence should be addressed.
Received: 26 February 2010 / Revised: 18 March 2010 / Accepted: 12 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
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Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
Keywords: oxidative stress; chemoprevention; chemotherapy oxidative stress; chemoprevention; chemotherapy

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bellezza, I.; Mierla, A.L.; Minelli, A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2010, 2, 483-497.

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