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Cancers 2010, 2(2), 364-375; doi:10.3390/cancers2020364

Cerebral Metastases from Malignant Melanoma: Current Treatment Strategies, Advances in Novel Therapeutics and Future Directions

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
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Received: 11 March 2010 / Revised: 25 March 2010 / Accepted: 1 April 2010 / Published: 6 April 2010
(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)
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Abstract

Of all primary cancers in humans, melanoma has the highest propensity to metastasize to the brain. The prognosis of patients with this disease is extremely poor. Due to its radioresistance and poor response to existing chemotherapeutic regimes, no treatment options other than surgical extirpation, when feasible, have been shown to be effective. An understanding of the underlying tumor biology therefore remains the cornerstone of offering new hope in the treatment. In this review, we comment on the current treatment strategies for melanoma brain metastases and summarize some recent experimental findings from our laboratory with potential for the development of target specific antitumor therapies. View Full-Text
Keywords: cerebral metastasis; melanoma; surgery; radiotherapy; drug therapy; STAT3 transcription factor cerebral metastasis; melanoma; surgery; radiotherapy; drug therapy; STAT3 transcription factor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Siu, T.L.; Huang, S. Cerebral Metastases from Malignant Melanoma: Current Treatment Strategies, Advances in Novel Therapeutics and Future Directions. Cancers 2010, 2, 364-375.

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