Next Article in Journal
Circulating Tumor Cells, Enumeration and Beyond
Next Article in Special Issue
Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging
Previous Article in Journal / Special Issue
Inflammatory Genetic Markers of Prostate Cancer Risk
Cancers 2010, 2(2), 1221-1235; doi:10.3390/cancers2021221
Review

Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer

1
, 1, 2, 2 and 1,*
1 Sandro Pitigliani’ Medical Oncology Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100, Prato, Italy 2 Translational Research Unit, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100, Prato, Italy
* Author to whom correspondence should be addressed.
Received: 10 May 2010 / Revised: 26 May 2010 / Accepted: 4 June 2010 / Published: 8 June 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
View Full-Text   |   Download PDF [193 KB, uploaded 8 June 2010]   |   Browse Figures

Abstract

Adjuvant systemic therapy targets minimal residual disease. Our current clinical approach in the adjuvant setting is to presume, rather than confirm, the presence of minimal residual disease. Based on assessment of the primary tumor, we estimate an individual’s recurrence risk. Subsequent treatment decisions are based on characteristics of the primary tumor, with the presumption of consistent biology and treatment sensitivity between micrometastases and the primary lesion. An alternative approach is to identify micrometastatic disease. Detection of disseminated tumor cells (DTC) in the bone marrow and circulating tumor cells (CTC) from peripheral blood collection may offer quantification and biocharacterization of residual disease. This paper will review the prognostic and predictive potential of micrometastatic disease in early breast cancer.
Keywords: breast cancer; adjuvant; micrometastases; circulating tumor cells; disseminated tumor cells breast cancer; adjuvant; micrometastases; circulating tumor cells; disseminated tumor cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Oakman, C.; Pestrin, M.; Bessi, S.; Galardi, F.; Di Leo, A. Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer. Cancers 2010, 2, 1221-1235.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert