Cancers 2010, 2(2), 1221-1235; doi:10.3390/cancers2021221
Review

Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer

1email, 1, 2, 2 and 1,* email
Received: 10 May 2010; in revised form: 26 May 2010 / Accepted: 4 June 2010 / Published: 8 June 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Adjuvant systemic therapy targets minimal residual disease. Our current clinical approach in the adjuvant setting is to presume, rather than confirm, the presence of minimal residual disease. Based on assessment of the primary tumor, we estimate an individual’s recurrence risk. Subsequent treatment decisions are based on characteristics of the primary tumor, with the presumption of consistent biology and treatment sensitivity between micrometastases and the primary lesion. An alternative approach is to identify micrometastatic disease. Detection of disseminated tumor cells (DTC) in the bone marrow and circulating tumor cells (CTC) from peripheral blood collection may offer quantification and biocharacterization of residual disease. This paper will review the prognostic and predictive potential of micrometastatic disease in early breast cancer.
Keywords: breast cancer; adjuvant; micrometastases; circulating tumor cells; disseminated tumor cells
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MDPI and ACS Style

Oakman, C.; Pestrin, M.; Bessi, S.; Galardi, F.; Di Leo, A. Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer. Cancers 2010, 2, 1221-1235.

AMA Style

Oakman C, Pestrin M, Bessi S, Galardi F, Di Leo A. Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer. Cancers. 2010; 2(2):1221-1235.

Chicago/Turabian Style

Oakman, Catherine; Pestrin, Marta; Bessi, Silvia; Galardi, Francesca; Di Leo, Angelo. 2010. "Significance of Micrometastases: Circulating Tumor Cells and Disseminated Tumor Cells in Early Breast Cancer." Cancers 2, no. 2: 1221-1235.

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