Cancers 2010, 2(1), 190-208; doi:10.3390/cancers2010190
Review

Cancer Biomarkers: Are We Ready for the Prime Time?

1,email and 2,,* email
Received: 20 February 2010; in revised form: 2 March 2010 / Accepted: 19 March 2010 / Published: 22 March 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. In cancer, a biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis and epidemiology. These markers can be assayed in non-invasively collected biofluids. However, few cancer biomarkers are highly sensitive and specific for cancer detection at the present time. Consequently, biomarkers are not yet ready for routine use due to challenges in their clinical validation for early disease detection, diagnosis and monitoring to improve long-term survival of patients.
Keywords: biomarker; cancer; diagnosis; glycans; prognosis; validation
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MDPI and ACS Style

Mishra, A.; Verma, M. Cancer Biomarkers: Are We Ready for the Prime Time? Cancers 2010, 2, 190-208.

AMA Style

Mishra A, Verma M. Cancer Biomarkers: Are We Ready for the Prime Time? Cancers. 2010; 2(1):190-208.

Chicago/Turabian Style

Mishra, Alok; Verma, Mukesh. 2010. "Cancer Biomarkers: Are We Ready for the Prime Time?" Cancers 2, no. 1: 190-208.

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