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• Ribatti, D
• Annese, T
• Longo, V
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• Annese, T
• Longo, V
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• Ribatti, D
• Annese, T
• Longo, V

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Cancers 2010, 2(1), 114-132; doi:10.3390/cancers2010114

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Angiogenesis and Melanoma

Domenico Ribatti* , Tiziana Annese and Vito Longo

Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy

* Author to whom correspondence should be addressed.

Received: 11 January 2010; in revised form: 10 February 2010 / Accepted: 24 February 2010 / Published: 25 February 2010

(This article belongs to the Special Issue Current Concepts in the Diagnosis and Treatment of Cutaneous Melanoma)

Download PDF Full-Text [476 KB, uploaded 25 February 2010 08:49 CET]

Abstract: Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host’s blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.

Keywords: angiogenesis; antiangiogenesis; human melanoma; tumor progression

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