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Cancers 2018, 10(5), 147; https://doi.org/10.3390/cancers10050147

Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL

1
Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia
2
ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, Australia
*
Author to whom correspondence should be addressed.
Received: 20 April 2018 / Revised: 11 May 2018 / Accepted: 16 May 2018 / Published: 18 May 2018
(This article belongs to the Special Issue The Role of Thrombosis and Haemostasis in Cancer)
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Abstract

The bloodstream typically contains >500 billion anucleate circulating platelets, derived from megakaryocytes in the bone marrow. This review will focus on two interesting aspects of bone marrow dysfunction and how this impacts on the quality of circulating platelets. In this regard, although megakaryocytes are from the myeloid lineage leading to granulocytes (including neutrophils), erythrocytes, and megakaryocytes/platelets, recent evidence has shown that defects in the lymphoid lineage leading to B cells, T cells, and natural killer (NK) cells also result in abnormal circulating platelets. Current evidence is limited regarding whether this latter phenomenon might potentially arise from (a) some form of as-yet-undetected defect common to both lineages; (b) adverse interactions occurring between cells of different lineages within the bone marrow environment; and/or (c) unknown disease-related factor(s) affecting circulating platelet receptor expression/function after their release from megakaryocytes. Understanding the mechanisms underlying how both myeloid and lymphoid lineage bone marrow defects lead to dysfunction of circulating platelets is significant because of the potential diagnostic and predictive value of peripheral platelet analysis for bone marrow disease progression, the additional potential effects of new anti-cancer drugs on platelet function, and the critical role platelets play in regulation of bleeding risk, inflammation, and innate immunity. View Full-Text
Keywords: platelets; bone marrow defects; glycoprotein Ibα; glycoprotein VI platelets; bone marrow defects; glycoprotein Ibα; glycoprotein VI
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Luu, S.; Gardiner, E.E.; Andrews, R.K. Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL. Cancers 2018, 10, 147.

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