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Cancers 2018, 10(2), 44; doi:10.3390/cancers10020044

Integrin Inhibitors in Prostate Cancer

1
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA
2
University of Puerto Rico Comprehensive Cancer Center, Medical Sciences Campus, San Juan, PR 00936, USA
*
Author to whom correspondence should be addressed.
Received: 21 November 2017 / Revised: 12 January 2018 / Accepted: 19 January 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Integrins in Cancer)
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Abstract

Prostate cancer (PCa) is the most frequently diagnosed cancer and the third highest cause of cancer-related deaths in men in the U.S. The development of chemotherapeutic agents that can bind PCa tumor cells with high specificity is critical in order to increase treatment effectiveness. Integrin receptors and their corresponding ligands have different expression patterns in PCa cells. They have been identified as promising targets to inhibit pathways involved in PCa progression. Currently, several compounds have proven to target specific integrins and their subunits in PCa cells. In this article, we review the role of integrins inhibitors in PCa and their potential as therapeutic targets for PCa treatments. We have discussed the following: natural compounds, monoclonal antibodies, statins, campothecins analog, aptamers, d-aminoacid, and snake venom. Recent studies have shown that their mechanisms of action result in decrease cell migration, cell invasion, cell proliferation, and metastasis of PCa cells. View Full-Text
Keywords: Gleditsia sinensis; d-pinitol; Abituzumab; d-aminoacid; Contortrostatin; α2β1; αvβ3; metastasis; PC3; 22RV1 Gleditsia sinensis; d-pinitol; Abituzumab; d-aminoacid; Contortrostatin; α2β1; αvβ3; metastasis; PC3; 22RV1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Juan-Rivera, M.C.; Martínez-Ferrer, M. Integrin Inhibitors in Prostate Cancer. Cancers 2018, 10, 44.

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