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Cancers 2018, 10(2), 45; https://doi.org/10.3390/cancers10020045

Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A-STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
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Received: 4 January 2018 / Revised: 5 February 2018 / Accepted: 5 February 2018 / Published: 6 February 2018
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Abstract

In addition to the structural and scaffolding role, the extracellular matrix (ECM) is emerging as a hub for biomechanical signal transduction that is frequently relayed to intracellular sensors to regulate diverse cellular processes. At a macroscopic scale, matrix rigidity confers long-ranging effects contributing towards tissue fibrosis and cancer. The transcriptional co-activators YAP/TAZ, better known as the converging effectors of the Hippo pathway, are widely recognized for their new role as nuclear mechanosensors during organ homeostasis and cancer. Still, how YAP/TAZ senses these “stiffness cues” from the ECM remains enigmatic. Here, we highlight the recent perspectives on the role of agrin in mechanosignaling from the ECM via antagonizing the Hippo pathway to activate YAP/TAZ in the contexts of cancer, neuromuscular junctions, and cardiac regeneration. View Full-Text
Keywords: Hippo pathway; agrin; YAP/TAZ; mechanotransduction; liver cancer; extracellular matrix; cardiac regeneration; neuromuscular junctions Hippo pathway; agrin; YAP/TAZ; mechanotransduction; liver cancer; extracellular matrix; cardiac regeneration; neuromuscular junctions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chakraborty, S.; Hong, W. Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond. Cancers 2018, 10, 45.

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