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Micromachines 2018, 9(1), 3; https://doi.org/10.3390/mi9010003

Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life

1
Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan
2
Research Center for Biomedical Devices, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Received: 30 October 2017 / Revised: 11 December 2017 / Accepted: 21 December 2017 / Published: 24 December 2017
(This article belongs to the Special Issue Biomedical Microdevices: Design, Fabrication and Application)
View Full-Text   |   Download PDF [4455 KB, uploaded 24 December 2017]   |  

Abstract

A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue life, without compromising other important clinical attributes. Our rhombic-shaped channel stent increases the total drug capacity by multiple times. Its fatigue safety factor, even with the large rhombic cutouts on the stent struts, could be 50% higher than that of the conventional drug-eluting stent. A pulsed fiber-optic laser and a series of expansions and heat treatments were used to make the first prototype of our rhombic-shaped channel stent. This new concept may open up a wide variety of new treatment options and opportunities for the medical industry in the future. View Full-Text
Keywords: drug-eluting stent; rhombic-shaped drug reservoir; programmable drug delivery; channel stent; depot stent drug-eluting stent; rhombic-shaped drug reservoir; programmable drug delivery; channel stent; depot stent
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Hsiao, H.-M.; Lin, C.-H.; Shen, Y.-K.; Chou, T.-Y.; Hsu, Y.-Y. Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life. Micromachines 2018, 9, 3.

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