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Micromachines 2017, 8(6), 186; doi:10.3390/mi8060186

Recent Advances and Future Perspectives on Microfluidic Liquid Handling

Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane, QLD 4111, Australia
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Author to whom correspondence should be addressed.
Academic Editor: Shih-Kang Fan
Received: 23 May 2017 / Revised: 3 June 2017 / Accepted: 8 June 2017 / Published: 12 June 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
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Abstract

The interdisciplinary research field of microfluidics has the potential to revolutionize current technologies that require the handling of a small amount of fluid, a fast response, low costs and automation. Microfluidic platforms that handle small amounts of liquid have been categorised as continuous-flow microfluidics and digital microfluidics. The first part of this paper discusses the recent advances of the two main and opposing applications of liquid handling in continuous-flow microfluidics: mixing and separation. Mixing and separation are essential steps in most lab-on-a-chip platforms, as sample preparation and detection are required for a variety of biological and chemical assays. The second part discusses the various digital microfluidic strategies, based on droplets and liquid marbles, for the manipulation of discrete microdroplets. More advanced digital microfluidic devices combining electrowetting with other techniques are also introduced. The applications of the emerging field of liquid-marble-based digital microfluidics are also highlighted. Finally, future perspectives on microfluidic liquid handling are discussed. View Full-Text
Keywords: continuous microfluidics; micromixers; cell separation; digital microfluidics; liquid marbles; electrowetting-on-dielectric (EWOD); microfluidic liquid handling continuous microfluidics; micromixers; cell separation; digital microfluidics; liquid marbles; electrowetting-on-dielectric (EWOD); microfluidic liquid handling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nguyen, N.-T.; Hejazian, M.; Ooi, C.H.; Kashaninejad, N. Recent Advances and Future Perspectives on Microfluidic Liquid Handling. Micromachines 2017, 8, 186.

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