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Micromachines 2017, 8(7), 204;

Microfluidic and Nanofluidic Resistive Pulse Sensing: A Review

Department of Marine Engineering, Dalian Maritime University, Dalian 116026, China
Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
Author to whom correspondence should be addressed.
Received: 17 April 2017 / Revised: 11 June 2017 / Accepted: 21 June 2017 / Published: 25 June 2017
(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
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The resistive pulse sensing (RPS) method based on the Coulter principle is a powerful method for particle counting and sizing in electrolyte solutions. With the advancement of micro- and nano-fabrication technologies, microfluidic and nanofluidic resistive pulse sensing technologies and devices have been developed. Due to the unique advantages of microfluidics and nanofluidics, RPS sensors are enabled with more functions with greatly improved sensitivity and throughput and thus have wide applications in fields of biomedical research, clinical diagnosis, and so on. Firstly, this paper reviews some basic theories of particle sizing and counting. Emphasis is then given to the latest development of microfuidic and nanofluidic RPS technologies within the last 6 years, ranging from some new phenomena, methods of improving the sensitivity and throughput, and their applications, to some popular nanopore or nanochannel fabrication techniques. The future research directions and challenges on microfluidic and nanofluidic RPS are also outlined. View Full-Text
Keywords: resistive pulse sensing; particle sizing and counting; microfluidics and nanofluidics; review resistive pulse sensing; particle sizing and counting; microfluidics and nanofluidics; review

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Song, Y.; Zhang, J.; Li, D. Microfluidic and Nanofluidic Resistive Pulse Sensing: A Review. Micromachines 2017, 8, 204.

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