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Micromachines 2016, 7(8), 131; doi:10.3390/mi7080131

Fabrication of a Cell Fixation Device for Robotic Cell Microinjection

School of Aerospace Engineering, Xiamen University, Xiamen 361005, China
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Author to whom correspondence should be addressed.
Academic Editors: Aaron T. Ohta and Wenqi Hu
Received: 21 June 2016 / Revised: 28 July 2016 / Accepted: 29 July 2016 / Published: 4 August 2016
(This article belongs to the Special Issue Microdevices and Microsystems for Cell Manipulation)
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Abstract

Automation of cell microinjection greatly reduces operational difficulty, but cell fixation remains a challenge. Here, we describe an innovative device that solves the fixation problem without single-cell operation. The microarray cylinder is designed with a polydimethylsiloxane (PDMS) material surface to control the contact force between cells and the material. Data show that when the injection velocity exceeds 1.5 mm/s, microinjection success rate is over 80%. The maximum value of the adhesion force between the PDMS plate and the cell is 0.0138 N, and the need can be met in practical use of the robotic microinjection. View Full-Text
Keywords: PDMS; microinjection; robotic; contact force PDMS; microinjection; robotic; contact force
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xie, Y.; Zhou, Y.; Xi, W.; Zeng, F.; Chen, S. Fabrication of a Cell Fixation Device for Robotic Cell Microinjection. Micromachines 2016, 7, 131.

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