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Micromachines 2016, 7(7), 123; doi:10.3390/mi7070123

Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans

1
Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
2
Department of Mechanical Engineering, York University, Toronto, ON M3J 1P3, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Manabu Tokeshi and Kiichi Sato
Received: 19 April 2016 / Revised: 23 June 2016 / Accepted: 11 July 2016 / Published: 19 July 2016
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
View Full-Text   |   Download PDF [8583 KB, uploaded 19 July 2016]   |  

Abstract

The nematode C. elegans (worm) is a small invertebrate animal widely used in studies related to fundamental biological processes, disease modelling, and drug discovery. Due to their small size and transparent body, these worms are highly suitable for experimental manipulations. In recent years several microfluidic devices and platforms have been developed to accelerate worm handling, phenotypic studies and screens. Here we review major tools and briefly discuss their usage in C. elegans research. View Full-Text
Keywords: C. elegans; microfluidics; live imaging; electrotaxis; neurobiology; high-throughput screening; drug discovery C. elegans; microfluidics; live imaging; electrotaxis; neurobiology; high-throughput screening; drug discovery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gupta, B.P.; Rezai, P. Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans. Micromachines 2016, 7, 123.

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