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Micromachines 2016, 7(7), 111; doi:10.3390/mi7070111

Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

1
Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
2
Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mußmann-Str. 1, Jülich 52428, Germany
3
Peter-Grünberg Institute (PGI-8), Research Centre Jülich, Jülich 52425, Germany
4
Department of Biomedical Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Manabu Tokeshi and Kiichi Sato
Received: 18 May 2016 / Revised: 17 June 2016 / Accepted: 28 June 2016 / Published: 1 July 2016
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
View Full-Text   |   Download PDF [1718 KB, uploaded 1 July 2016]   |  

Abstract

A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement. View Full-Text
Keywords: chemical sensor; plug-based microfluidic device; light-addressable potentiometric sensor chemical sensor; plug-based microfluidic device; light-addressable potentiometric sensor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Miyamoto, K.-I.; Sato, T.; Abe, M.; Wagner, T.; Schöning, M.J.; Yoshinobu, T. Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices. Micromachines 2016, 7, 111.

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