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Micromachines 2016, 7(11), 199; doi:10.3390/mi7110199

Microfluidic Paper-Based Sample Concentration Using Ion Concentration Polarization with Smartphone Detection

Institute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
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Author to whom correspondence should be addressed.
Academic Editors: Xiangchun Xuan and Shizhi Qian
Received: 30 September 2016 / Revised: 29 October 2016 / Accepted: 1 November 2016 / Published: 4 November 2016
(This article belongs to the Special Issue Micro/Nano-Chip Electrokinetics)
View Full-Text   |   Download PDF [3316 KB, uploaded 4 November 2016]   |  

Abstract

A simple method for microfluidic paper-based sample concentration using ion concentration polarization (ICP) with smartphone detection is developed. The concise and low-cost microfluidic paper-based ICP analytical device, which consists of a black backing layer, a nitrocellulose membrane, and two absorbent pads, is fabricated with the simple lamination method which is widely used for lateral flow strips. Sample concentration on the nitrocellulose membrane is monitored in real time by a smartphone whose camera is used to collect the fluorescence images from the ICP device. A custom image processing algorithm running on the smartphone is used to track the concentrated sample and obtain its fluorescence signal intensity for quantitative analysis. Two different methods for Nafion coating are evaluated and their performances are compared. The characteristics of the ICP analytical device especially with intentionally adjusted physical properties are fully evaluated to optimize its performance as well as to extend its potential applications. Experimental results show that significant concentration enhancement with fluorescence dye sample is obtained with the developed ICP device when a fast depletion of fluorescent dye is observed. The platform based on the simply laminated ICP device with smartphone detection is desired for point-of-care testing in settings with poor resources. View Full-Text
Keywords: ion concentration polarization (ICP); sample concentration; paper-based microfluidics; Nafion coating; smartphone; point-of-care test ion concentration polarization (ICP); sample concentration; paper-based microfluidics; Nafion coating; smartphone; point-of-care test
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, X.; Niu, Y.; Chen, Y.; Wu, D.; Yi, L.; Qiu, X. Microfluidic Paper-Based Sample Concentration Using Ion Concentration Polarization with Smartphone Detection. Micromachines 2016, 7, 199.

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