Temperature Sensing in Modular Microfluidic Architectures
AbstractA discrete microfluidic element with integrated thermal sensor was fabricated and demonstrated as an effective probe for process monitoring and prototyping. Elements were constructed using stereolithography and market-available glass-bodied thermistors within the modular, standardized framework of previous discrete microfluidic elements demonstrated in the literature. Flow rate-dependent response due to sensor self-heating and microchannel heating and cooling was characterized and shown to be linear in typical laboratory conditions. An acid-base neutralization reaction was performed in a continuous flow setting to demonstrate applicability in process management: the ratio of solution flow rates was varied to locate the equivalence point in a titration, closely matching expected results. This element potentially enables complex, three-dimensional microfluidic architectures with real-time temperature feedback and flow rate sensing, without application specificity or restriction to planar channel routing formats. View Full-Text
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Bhargava, K.C.; Thompson, B.; Tembhekar, A.; Malmstadt, N. Temperature Sensing in Modular Microfluidic Architectures. Micromachines 2016, 7, 11.
Bhargava KC, Thompson B, Tembhekar A, Malmstadt N. Temperature Sensing in Modular Microfluidic Architectures. Micromachines. 2016; 7(1):11.Chicago/Turabian Style
Bhargava, Krisna C.; Thompson, Bryant; Tembhekar, Anoop; Malmstadt, Noah. 2016. "Temperature Sensing in Modular Microfluidic Architectures." Micromachines 7, no. 1: 11.
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