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Micromachines 2015, 6(7), 915-925;

A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection

Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430000, China
Both authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Andrew deMell and Xavier Casadevall i Solvas
Received: 12 June 2015 / Revised: 6 July 2015 / Accepted: 6 July 2015 / Published: 13 July 2015
(This article belongs to the Special Issue Droplet Microfluidics: Techniques and Technologies)
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A microfluidic droplet mixer is developed for rapid detection of Hg(II) ions. Reagent concentration and droplets can be precisely controlled by adjusting the flow rates of different fluid phases. By selecting suitable flow rates of the oil phase, probe phase and sample phase, probe droplets and sample droplets can be matched and merged in pairs and subsequently well-mixed in the poly (dimethylsiloxane) (PDMS) channels. The fluorescence enhancement probe (Rhodamine B mixed with gold nanoparticles) encapsulated in droplets can react with Hg(II) ions. The Hg(II) ion concentration in the sample droplets is adjusted from about 0 to 1000 nM through fluid regulation to simulate possible various contaminative water samples. The intensity of the emission fluorescence is sensitive to Hg(II) ions (increases as the Hg(II) ion concentration increases). Through the analysis of the acquired fluorescence images, the concentration of Hg(II) ions can be precisely detected. With the advantages of less time, cost consumption and easier manipulations, this device would have a great potential in micro-scale sample assays and real-time chemical reaction studies. View Full-Text
Keywords: microfluidic; droplet; mixer; Hg(II) ion; gold nanoparticle microfluidic; droplet; mixer; Hg(II) ion; gold nanoparticle

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Meng, Q.-F.; Rao, L.; Cai, B.; You, S.-J.; Guo, S.-S.; Liu, W.; Zhao, X.-Z. A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection. Micromachines 2015, 6, 915-925.

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