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Micromachines 2015, 6(8), 1180-1188; doi:10.3390/mi6081180

Centrifugal Step Emulsification can Produce Water in Oil Emulsions with Extremely High Internal Volume Fractions

1
Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
2
Laboratory for MEMS Applications, IMTEK — Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
3
BIOSS — Centre for Biological Signalling Studies, University of Freiburg, 79110 Freiburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Andrew deMello and Xavier Casadevall i Solvas
Received: 22 July 2015 / Revised: 11 August 2015 / Accepted: 17 August 2015 / Published: 20 August 2015
(This article belongs to the Special Issue Droplet Microfluidics: Techniques and Technologies)
View Full-Text   |   Download PDF [4955 KB, uploaded 20 August 2015]   |  

Abstract

The high throughput preparation of emulsions with high internal volume fractions is important for many different applications, e.g., drug delivery. However, most emulsification techniques reach only low internal volume fractions and need stable flow rates that are often difficult to control. Here, we present a centrifugal high throughput step emulsification disk for the fast and easy production of emulsions with high internal volume fractions above 95%. The disk produces droplets at generation rates of up to 3700 droplets/s and, for the first time, enables the generation of emulsions with internal volume fractions of >97%. The coefficient of variation between droplet sizes is very good (4%). We apply our system to show the in situ generation of gel emulsion. In the future, the recently introduced unit operation of centrifugal step emulsification may be used for the high throughput production of droplets as reaction compartments for clinical diagnostics or as starting material for micromaterial synthesis. View Full-Text
Keywords: droplet; high-throughput; centrifugal step emulsification; step emulsification; centrifugal microfluidics; internal phase ratio; internal volume fraction; high internal phase ratio emulsion (HIPRE) droplet; high-throughput; centrifugal step emulsification; step emulsification; centrifugal microfluidics; internal phase ratio; internal volume fraction; high internal phase ratio emulsion (HIPRE)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Schuler, F.; Paust, N.; Zengerle, R.; von Stetten, F. Centrifugal Step Emulsification can Produce Water in Oil Emulsions with Extremely High Internal Volume Fractions. Micromachines 2015, 6, 1180-1188.

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