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Micromachines 2015, 6(12), 1890-1902; doi:10.3390/mi6121463

Three-Dimensional Electro-Sonic Flow Focusing Ionization Microfluidic Chip for Mass Spectrometry

1,‡,* , 2
Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
The State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, Beijing 100084, China
This paper is an extended version of our paper presented in the 17th Annual Conference of the Chinese Society of Micro-Nano Technology, Shanghai, China, 11–14 October 2015.
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editors: Manabu Tokeshi and Kiichi Sato
Received: 9 November 2015 / Revised: 30 November 2015 / Accepted: 1 December 2015 / Published: 4 December 2015
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
View Full-Text   |   Download PDF [4704 KB, uploaded 7 December 2015]   |  


Increasing research efforts have been recently devoted to the coupling of microfluidic chip-integrated ionization sources to mass spectrometry (MS). Considering the limitations of microfluidic chips coupled with MS such as liquid spreading, dead volume, and manufacturing troubles, this paper proposed a new three-dimensional (3D) flow focusing (FF)-based microfluidic ionizing source. This source was fabricated by using the two-layer soft lithography method with the nozzle placed inside the chip. The proposed FF microfluidic chip can realize two-phase FF with liquid in air regardless of the viscosity ratio of the continuous and dispersed phases. MS results indicated that the proposed FF microfluidic chip can work as a typical electrical ionization source when supplied with high voltage and can serve as a sonic ionization source without high voltage. The electro-sonic FF ionization microfluidic chip is expected to have various applications, particularly in the integrated and portable applications of ionization sources coupling with portable MS in the future. View Full-Text
Keywords: microfluidic chip; ionization; electro-sonic flow focusing; two-phase flow; soft lithography; mass spectrometry microfluidic chip; ionization; electro-sonic flow focusing; two-phase flow; soft lithography; mass spectrometry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yu, C.; Qian, X.; Chen, Y.; Yu, Q.; Ni, K.; Wang, X. Three-Dimensional Electro-Sonic Flow Focusing Ionization Microfluidic Chip for Mass Spectrometry. Micromachines 2015, 6, 1890-1902.

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