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Micromachines 2014, 5(2), 154-157; doi:10.3390/mi5020154

Micro/Nanofluidic Devices for Single Cell Analysis

1 Institute of Nano Engineering and Microsystems, National Tsing Hua University, Kuang Fu Road, No. 101, Section 2, Hsinchu 30013, Taiwan 2 Department of Engineering and System Science, National Tsing Hua University, Kuang Fu Road, No. 101, Section 2, Hsinchu 30013, Taiwan 3 Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Nankang, 11574, Taipei, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 March 2014 / Accepted: 28 March 2014 / Published: 3 April 2014
(This article belongs to the Special Issue Micro/Nanofluidic Devices for Single Cell Analysis)
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Note: In lieu of an abstract, this is an excerpt from the first page.


The Special Issue of Micromachines entitled “Micro/Nanofluidic Devices for Single Cell Analysis” covers recent advancements regarding the analysis of single cells by different microfluidic approaches. To understand cell to cell behavior with their organelles and their intracellular biochemical effect, single cell analysis (SCA) can provide much more detailed information from small groups of cells or even single cells, compared to conventional approaches, which only provide ensemble-average information of millions of cells together. Earlier reviews provided single cell analysis using different approaches [1–3]. The author demonstrates invasive and noninvasive with time and non-time resolved SCA [1]; whereas some other literature provided destructive (with dyes, DNA, RNA, proteins and amino acids) and nondestructive (electroporation, impedance measurement and fluorescence based methods) cellular content analysis using microfluidic devices [3]. Further literature also suggest that single cell analysis is possible with capillary electrophoresis (CE) combined with a detection method such as electrochemical detection (ED), laser induced fluorescence (LIF) detection and mass spectrometry (MS) [4,5]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Santra, T.S.; Tseng, F.G. Micro/Nanofluidic Devices for Single Cell Analysis. Micromachines 2014, 5, 154-157.

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