Micromachines 2013, 4(1), 80-89; doi:10.3390/mi4010080
Article

Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array

1,4,* email, 1email, 1,2,3email and 1,2email
Received: 17 December 2012; in revised form: 11 February 2013 / Accepted: 1 March 2013 / Published: 14 March 2013
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Abstract: We present a continuous-flow active micromixer based on channel-wall deflection in a polydimethylsiloxane (PDMS) chip for volume flows in the range up to 2 μL s−1 which is intended as a novel unit operation for the microfluidic Braille pin actuated platform. The chip design comprises a main microchannel connected to a series of side channels with dead ends aligned on the Braille pins. Computer-controlled deflection of the side-channel walls induces chaotic advection in the main-channel, which substantially accelerates mixing in low-Reynolds number flow. Sufficient mixing (mixing index MI below 0.1) of volume flows up to 0.5 μL s−1 could be achieved within residence times ~500 ms in the micromixer. As an application, continuous dilution of a yeast cell sample by a ratio down to 1:10 was successfully demonstrated. The mixer is intended to serve as a component of bio-analytical devices or as a unit operation in the microfluidic Braille pin actuated platform.
Keywords: active micromixer; continuous-flow; chaotic advection; channel wall deflection; PDMS chip; cell sample dilution; microfluidic Braille pin actuated platform
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Abbas, Y.; Miwa, J.; Zengerle, R.; von Stetten, F. Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array. Micromachines 2013, 4, 80-89.

AMA Style

Abbas Y, Miwa J, Zengerle R, von Stetten F. Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array. Micromachines. 2013; 4(1):80-89.

Chicago/Turabian Style

Abbas, Yawar; Miwa, Junichi; Zengerle, Roland; von Stetten, Felix. 2013. "Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array." Micromachines 4, no. 1: 80-89.


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