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Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array
Laboratory for MEMS Applications, Department of Microsystems Engineering, IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
HSG-IMIT, Institut für Mikro- und Informationstechnik, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
BIOSS—Centre for Biological Signalling Studies, University Freiburg, 79104 Freiburg, Germany
BIOS-Lab on chip group, MESA+ Institution of Nanotechnology, University of Twente, 7522 NH Enschede, The Netherlands
* Author to whom correspondence should be addressed.
Received: 17 December 2012; in revised form: 11 February 2013 / Accepted: 1 March 2013 / Published: 14 March 2013
Abstract: We present a continuous-flow active micromixer based on channel-wall deflection in a polydimethylsiloxane (PDMS) chip for volume flows in the range up to 2 μL s−1 which is intended as a novel unit operation for the microfluidic Braille pin actuated platform. The chip design comprises a main microchannel connected to a series of side channels with dead ends aligned on the Braille pins. Computer-controlled deflection of the side-channel walls induces chaotic advection in the main-channel, which substantially accelerates mixing in low-Reynolds number flow. Sufficient mixing (mixing index MI below 0.1) of volume flows up to 0.5 μL s−1 could be achieved within residence times ~500 ms in the micromixer. As an application, continuous dilution of a yeast cell sample by a ratio down to 1:10 was successfully demonstrated. The mixer is intended to serve as a component of bio-analytical devices or as a unit operation in the microfluidic Braille pin actuated platform.
Keywords: active micromixer; continuous-flow; chaotic advection; channel wall deflection; PDMS chip; cell sample dilution; microfluidic Braille pin actuated platform
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MDPI and ACS Style
Abbas, Y.; Miwa, J.; Zengerle, R.; von Stetten, F. Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array. Micromachines 2013, 4, 80-89.
Abbas Y, Miwa J, Zengerle R, von Stetten F. Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array. Micromachines. 2013; 4(1):80-89.
Abbas, Yawar; Miwa, Junichi; Zengerle, Roland; von Stetten, Felix. 2013. "Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array." Micromachines 4, no. 1: 80-89.