Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

doi:10.3390/mi3040615

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Micromachines 2012, 3(4), 615-631; doi:10.3390/mi3040615

Review

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

Danny Jian Hang Tng¹, Rui Hu¹, Peiyi Song¹, Indrajit Roy² and Ken-Tye Yong^1,*

¹ School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore ² Department of Chemistry, University of Delhi, Delhi 110 007, India

* Author to whom correspondence should be addressed.

Received: 13 September 2012; in revised form: 2 November 2012 / Accepted: 7 November 2012 / Published: 14 November 2012

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Abstract: Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

Keywords: MEMS device; drug delivery; biomedical applications; implantable

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MDPI and ACS Style

Tng, D.J.H.; Hu, R.; Song, P.; Roy, I.; Yong, K.-T. Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications. Micromachines 2012, 3, 615-631.

AMA Style

Tng DJH, Hu R, Song P, Roy I, Yong K-T. Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications. Micromachines. 2012; 3(4):615-631.

Chicago/Turabian Style

Tng, Danny J.H.; Hu, Rui; Song, Peiyi; Roy, Indrajit; Yong, Ken-Tye. 2012. "Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications." Micromachines 3, no. 4: 615-631.

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