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Optimization of Liquid DiElectroPhoresis (LDEP) Digital Microfluidic Transduction for Biomedical Applications
CEA-LETI, Department of Technology for Biology and Health, 38054 Grenoble, France
LIMMS-CNRS/IIS(UMI 2820), The University of Tokyo, 153-8505 Tokyo, Japan
Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan
* Author to whom correspondence should be addressed.
Received: 5 April 2011; in revised form: 22 May 2011 / Accepted: 25 May 2011 / Published: 3 June 2011
Abstract: Digital microfluidic has recently been under intensive study, as an effective method to carry out liquid manipulation in Lab-On-a-Chip (LOC) systems. Among droplet actuation forces, ElectroWetting on Dielectric (EWOD) and Liquid DiElectroPhoresis (LDEP) are powerful tools, used in many LOC platforms. Such digital microfluidic transductions do not require integration of complex mechanical components such as pumps and valves to perform the fluidic operations. However, although LDEP has been proved to be efficient to carry and manipulate biological components in insulating liquids, this microfluidic transduction requires several hundreds of volts at relatively high frequencies (kHz to MHz). With the purpose to develop integrated microsystems µ-TAS (Micro Total Analysis System) or Point of Care systems, the goal here is to reduce such high actuation voltage, the power consumption, though using standard dielectric materials. This paper gives key rules to determine the best tradeoff between liquid manipulation efficiency, low-power consumption and robustness of microsystems using LDEP actuation. This study leans on an electromechanical model to describe liquid manipulation that is applied to an experimental setup, and provides precise quantification of both actuation voltage Vth and frequency fc thresholds between EWOD and LDEP regimes. In particular, several parameters will be investigated to quantify Vth and fc, such as the influence of the chip materials, the electrodes size and the device configurations. Compared to current studies in the field, significant reduction of both Vth and fc is achieved by optimization of the aforementioned parameters.
Keywords: liquid dielectrophoresis; dielectric high-k material; electromechanical force; open-microfluidic and parallel-plate microfluidic
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MDPI and ACS Style
Renaudot, R.; Agache, V.; Daunay, B.; Lambert, P.; Kumemura, M.; Fouillet, Y.; Collard, D.; Fujita, H. Optimization of Liquid DiElectroPhoresis (LDEP) Digital Microfluidic Transduction for Biomedical Applications. Micromachines 2011, 2, 258-273.
Renaudot R, Agache V, Daunay B, Lambert P, Kumemura M, Fouillet Y, Collard D, Fujita H. Optimization of Liquid DiElectroPhoresis (LDEP) Digital Microfluidic Transduction for Biomedical Applications. Micromachines. 2011; 2(2):258-273.
Renaudot, Raphaël; Agache, Vincent; Daunay, Bruno; Lambert, Pierre; Kumemura, Momoko; Fouillet, Yves; Collard, Dominique; Fujita, Hiroyuki. 2011. "Optimization of Liquid DiElectroPhoresis (LDEP) Digital Microfluidic Transduction for Biomedical Applications." Micromachines 2, no. 2: 258-273.