Next Article in Journal
Does the Host Contribute to Modulation of Mycotoxin Production by Fruit Pathogens?
Next Article in Special Issue
Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications
Previous Article in Journal
Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice
Previous Article in Special Issue
Molecular Modeling of the Catalytic Domain of CyaA Deepened the Knowledge of Its Functional Dynamics
Article Menu

Export Article

Open AccessReview
Toxins 2017, 9(9), 277; doi:10.3390/toxins9090277

Bordetella Adenylate Cyclase-Hemolysin Toxins

Institut Pasteur Unité de Prévention et Thérapies Moléculaires des Maladies Humaines, 25 rue du Dr. Roux, 75015 Paris, France
Academic Editor: Joachim Orth
Received: 22 August 2017 / Revised: 3 September 2017 / Accepted: 7 September 2017 / Published: 11 September 2017
(This article belongs to the Special Issue Adenylate Cyclase (CyaA) Toxin)
View Full-Text   |   Download PDF [275 KB, uploaded 11 September 2017]

Abstract

Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica. This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these Bordetella species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses. In contrast with other Bordetella toxins or adhesins, lack of (or very low polymorphism) is observed in the structural gene encoding this toxin, supporting its importance as well as a potential role as a vaccine antigen against whooping cough. In this article, an overview of the investigations undertaken on this toxin is presented. View Full-Text
Keywords: Bordetella species; adenylate cyclase toxin; vaccine antigen Bordetella species; adenylate cyclase toxin; vaccine antigen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Guiso, N. Bordetella Adenylate Cyclase-Hemolysin Toxins. Toxins 2017, 9, 277.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top