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Toxins 2017, 9(9), 277;

Bordetella Adenylate Cyclase-Hemolysin Toxins

Institut Pasteur Unité de Prévention et Thérapies Moléculaires des Maladies Humaines, 25 rue du Dr. Roux, 75015 Paris, France
Academic Editor: Joachim Orth
Received: 22 August 2017 / Revised: 3 September 2017 / Accepted: 7 September 2017 / Published: 11 September 2017
(This article belongs to the Special Issue Adenylate Cyclase (CyaA) Toxin)
View Full-Text   |   Download PDF [275 KB, uploaded 11 September 2017]


Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica. This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these Bordetella species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses. In contrast with other Bordetella toxins or adhesins, lack of (or very low polymorphism) is observed in the structural gene encoding this toxin, supporting its importance as well as a potential role as a vaccine antigen against whooping cough. In this article, an overview of the investigations undertaken on this toxin is presented. View Full-Text
Keywords: Bordetella species; adenylate cyclase toxin; vaccine antigen Bordetella species; adenylate cyclase toxin; vaccine antigen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guiso, N. Bordetella Adenylate Cyclase-Hemolysin Toxins. Toxins 2017, 9, 277.

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