The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species
AbstractFish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10–100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 μg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve‐muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration‐dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post‐synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Han, H.; Baumann, K.; Casewell, N.R.; Ali, S.A.; Dobson, J.; Koludarov, I.; Debono, J.; Cutmore, S.C.; Rajapakse, N.W.; Jackson, T.N.W.; Jones, R.; Hodgson, W.C.; Fry, B.G.; Kuruppu, S. The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species. Toxins 2017, 9, 67.
Han H, Baumann K, Casewell NR, Ali SA, Dobson J, Koludarov I, Debono J, Cutmore SC, Rajapakse NW, Jackson TNW, Jones R, Hodgson WC, Fry BG, Kuruppu S. The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species. Toxins. 2017; 9(2):67.Chicago/Turabian Style
Han, Han; Baumann, Kate; Casewell, Nicholas R.; Ali, Syed A.; Dobson, James; Koludarov, Ivan; Debono, Jordan; Cutmore, Scott C.; Rajapakse, Niwanthi W.; Jackson, Timothy N.W.; Jones, Rob; Hodgson, Wayne C.; Fry, Bryan G.; Kuruppu, Sanjaya. 2017. "The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species." Toxins 9, no. 2: 67.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.