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Toxins 2017, 9(10), 300; doi:10.3390/toxins9100300

Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

1
Institute of Microbiology of the CAS, v.v.i., 142 20 Prague, Czech Republic
2
Faculty of Science, Charles University in Prague, 128 43 Prague, Czech Republic
Present address: MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandre Chenal
Received: 29 August 2017 / Revised: 19 September 2017 / Accepted: 21 September 2017 / Published: 24 September 2017
(This article belongs to the Special Issue Adenylate Cyclase (CyaA) Toxin)
View Full-Text   |   Download PDF [2446 KB, uploaded 23 October 2017]   |  

Abstract

Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely catalytically active adenylyl cyclase enzyme is delivered into phagocyte cytosol by a pore-forming repeat-in-toxin (RTX) cytolysin moiety. By targeting sentinel cells expressing the complement receptor 3, known as the CD11b/CD18 (αMβ2) integrin, CyaA compromises the bactericidal functions of host phagocytes and supports infection of host airways by Bordetellae. Here, we review the state of knowledge on structural and functional aspects of CyaA toxin action, placing particular emphasis on signaling mechanisms by which the toxin-produced 3′,5′-cyclic adenosine monophosphate (cAMP) subverts the physiology of phagocytic cells. View Full-Text
Keywords: adenylate cyclase toxin; Bordetella; β2 integrins; cAMP; CD11b/CD18; cell signaling; complement receptor 3; innate immunity; membrane pores; repeats-in-toxin adenylate cyclase toxin; Bordetella; β2 integrins; cAMP; CD11b/CD18; cell signaling; complement receptor 3; innate immunity; membrane pores; repeats-in-toxin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Novak, J.; Cerny, O.; Osickova, A.; Linhartova, I.; Masin, J.; Bumba, L.; Sebo, P.; Osicka, R. Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes. Toxins 2017, 9, 300.

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