Table of Contents
Toxins, Volume 9, Issue 10 (October 2017)
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Cover Story (view full-size image) The aim of the AntiBotABE Program was the development of recombinant antibodies neutralizing [...] Read more. The aim of the AntiBotABE Program was the development of recombinant antibodies neutralizing botulinum neurotoxins (BoNT) A, B and E, responsible for most human botulism cases. Macaques were immunized with the recombinant non-toxic BoNT/A, B or E, heavy and light chains, followed by the generation of immune phage-display libraries. Selected antibodies were analyzed in in vitro and ex vivo assays. The best neutralizing antibodies were germline-humanized, expressed as IgGs and protection was analzyed in two different in vivo models showing a synergistic effect when combining anti-heavy and anti-light chains antibodies. These germline humanized antibodies are promising candidates for further regulatory and clinical development. View Paper here