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Toxins 2017, 9(10), 293; https://doi.org/10.3390/toxins9100293

Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

1
Department of Infectious Diseases, Istituto Superiore di Sanità, Rome 00161, Italy
2
Sotio a.s, Prague170 00, Czech Republic
3
Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 00, Czech Republic
4
Institute of Microbiology of the CAS, v. v. i., Prague 142 20, Czech Republic
5
Faculty of Science, Charles University in Prague, Prague 128 00, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandre Chenal
Received: 25 August 2017 / Revised: 14 September 2017 / Accepted: 15 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Adenylate Cyclase (CyaA) Toxin)
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Abstract

Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3′,5′-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells. CyaA-induced cAMP signaling swiftly incapacitates opsonophagocytosis, oxidative burst and NO-mediated killing of bacteria by neutrophils and macrophages. The subversion of host immune responses by CyaA after delivery into DC, macrophages and neutrophils is the subject of this review. View Full-Text
Keywords: immune response; intracellular pathways; phagocytosis; T-helper cells immune response; intracellular pathways; phagocytosis; T-helper cells
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Fedele, G.; Schiavoni, I.; Adkins, I.; Klimova, N.; Sebo, P. Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity. Toxins 2017, 9, 293.

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