Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
AbstractSnake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims. The effectiveness of SVMPs is greatly due to their functional diversity, targeting important physiological proteins or receptors in different tissues and in the coagulation system. Functional diversity is often related to the genetic diversification of the snake venom. In this review, we discuss some published evidence that posit that processing and post-translational modifications are great contributors for the generation of functional diversity and for maintaining latency or inactivation of enzymes belonging to this relevant family of venom toxins. View Full-Text
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Moura-da-Silva, A.M.; Almeida, M.T.; Portes-Junior, J.A.; Nicolau, C.A.; Gomes-Neto, F.; Valente, R.H. Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation. Toxins 2016, 8, 183.
Moura-da-Silva AM, Almeida MT, Portes-Junior JA, Nicolau CA, Gomes-Neto F, Valente RH. Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation. Toxins. 2016; 8(6):183.Chicago/Turabian Style
Moura-da-Silva, Ana M.; Almeida, Michelle T.; Portes-Junior, José A.; Nicolau, Carolina A.; Gomes-Neto, Francisco; Valente, Richard H. 2016. "Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation." Toxins 8, no. 6: 183.
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