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Toxins 2016, 8(3), 81; doi:10.3390/toxins8030081

Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction

Lipella Pharmaceuticals, Pittsburgh, PA 19019, USA
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Academic Editor: Hann-Chorng Kuo
Received: 3 February 2016 / Revised: 26 February 2016 / Accepted: 29 February 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Botulinum Toxin A on Lower Urinary Tract Dysfunction)
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Abstract

Bladder drug delivery via catheter instillation is a widely used treatment for recurrence of superficial bladder cancer. Intravesical instillation of liposomal botulinum toxin has recently shown promise in the treatment of overactive bladder and interstitial cystitis/bladder pain syndrome, and studies of liposomal tacrolimus instillations show promise in the treatment of hemorrhagic cystitis. Liposomes are lipid vesicles composed of phospholipid bilayers surrounding an aqueous core that can encapsulate hydrophilic and hydrophobic drug molecules to be delivered to cells via endocytosis. This review will present new developments on instillations of liposomes and liposome-encapsulated drugs into the urinary bladder for treating lower urinary tract dysfunction. View Full-Text
Keywords: liposome; bladder; interstitial cystitis; overactive bladder; botulinum toxin liposome; bladder; interstitial cystitis; overactive bladder; botulinum toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Janicki, J.J.; Chancellor, M.B.; Kaufman, J.; Gruber, M.A.; Chancellor, D.D. Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction. Toxins 2016, 8, 81.

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