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Toxins 2016, 8(3), 71; doi:10.3390/toxins8030071

Mast Cell Targeted Chimeric Toxin Can Be Developed as an Adjunctive Therapy in Colon Cancer Treatment

1
The Second Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Clinical Specialty in Allergy, The State Key Laboratory of Respiratory Disease; Guangzhou 510260, China
2
The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
*
Author to whom correspondence should be addressed.
Academic Editor: C. Chris Yun
Received: 5 January 2016 / Revised: 22 February 2016 / Accepted: 23 February 2016 / Published: 11 March 2016
(This article belongs to the Section Bacterial Toxins)
View Full-Text   |   Download PDF [2747 KB, uploaded 11 March 2016]   |  

Abstract

The association of colitis with colorectal cancer has become increasingly clear with mast cells being identified as important inflammatory cells in the process. In view of the relationship between mast cells and cancer, we studied the effect and mechanisms of mast cells in the development of colon cancer. Functional and mechanistic insights were gained from ex vivo and in vivo studies of cell interactions between mast cells and CT26 cells. Further evidence was reversely obtained in studies of mast cell targeted Fcε-PE40 chimeric toxin. Experiments revealed mast cells could induce colon tumor cell proliferation and invasion. Cancer progression was found to be related to the density of mast cells in colonic submucosa. The activation of MAPK, Rho-GTPase, and STAT pathways in colon cancer cells was triggered by mast cells during cell-to-cell interaction. Lastly, using an Fcε-PE40 chimeric toxin we constructed, we confirmed the promoting effect of mast cells in development of colon cancer. Mast cells are a promoting factor of colon cancer and thus also a potential therapeutic target. The Fcε-PE40 chimeric toxin targeting mast cells could effectively prevent colon cancer in vitro and in vivo. Consequently, these data may demonstrate a novel immunotherapeutic approach for the treatment of tumors. View Full-Text
Keywords: colon cancer; tumor microenvironment; chimeric toxin; Fcε-PE40; mast cell colon cancer; tumor microenvironment; chimeric toxin; Fcε-PE40; mast cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, S.; Li, L.; Shi, R.; Liu, X.; Zhang, J.; Zou, Z.; Hao, Z.; Tao, A. Mast Cell Targeted Chimeric Toxin Can Be Developed as an Adjunctive Therapy in Colon Cancer Treatment. Toxins 2016, 8, 71.

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