Next Article in Journal
Development of a Rapid LC-MS/MS Method for the Determination of Emerging Fusarium mycotoxins Enniatins and Beauvericin in Human Biological Fluids
Next Article in Special Issue
Titanium Dioxide Nanoparticles (TiO2) Quenching Based Aptasensing Platform: Application to Ochratoxin A Detection
Previous Article in Journal
Correction: Sangare, L., et al. Aflatoxin B1 Degradation by a Pseudomonas Strain. Toxins 2014, 6, 3028–3040
Previous Article in Special Issue
Development of a Monoclonal Antibody-Based icELISA for the Detection of Ustiloxin B in Rice False Smut Balls and Rice Grains
Article Menu

Export Article

Open AccessArticle
Toxins 2015, 7(9), 3540-3553; doi:10.3390/toxins7093540

Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework

1
University of Lyon, Institute of Analytical Sciences, UMR-CNRS 5280, La Doua Street, 5, Villeurbanne 69100, France
2
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
3
University of Lyon, Laboratoire Hubert Curien, UMR 5516, Jean-Monnet University of Saint-Etienne, Saint-Etienne F-42023, France
*
Author to whom correspondence should be addressed.
Academic Editor: Maria C. DeRosa
Received: 8 July 2015 / Revised: 10 August 2015 / Accepted: 25 August 2015 / Published: 7 September 2015
(This article belongs to the Collection Biorecognition Assays for Mycotoxins)
View Full-Text   |   Download PDF [1923 KB, uploaded 7 September 2015]   |  

Abstract

A sensitive electrochemical molecularly-imprinted sensor was developed for the detection of aflatoxin B1 (AFB1), by electropolymerization of p-aminothiophenol-functionalized gold nanoparticles in the presence of AFB1 as a template molecule. The extraction of the template leads to the formation of cavities that are able to specifically recognize and bind AFB1 through π-π interactions between AFB1 molecules and aniline moities. The performance of the developed sensor for the detection of AFB1 was investigated by linear sweep voltammetry using a hexacyanoferrate/hexacyanoferrite solution as a redox probe, the electron transfer rate increasing when the concentration of AFB1 increases, due to a p-doping effect. The molecularly-imprinted sensor exhibits a broad linear range, between 3.2 fM and 3.2 µM, and a quantification limit of 3 fM. Compared to the non-imprinted sensor, the imprinting factor was found to be 10. Selectivity studies were also performed towards the binding of other aflatoxins and ochratoxin A, proving good selectivity. View Full-Text
Keywords: electrochemical sensors; aflatoxin B1; molecularly imprinted polymers; metal organic framework; gold nanoparticles electrochemical sensors; aflatoxin B1; molecularly imprinted polymers; metal organic framework; gold nanoparticles
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jiang, M.; Braiek, M.; Florea, A.; Chrouda, A.; Farre, C.; Bonhomme, A.; Bessueille, F.; Vocanson, F.; Zhang, A.; Jaffrezic-Renault, N. Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework. Toxins 2015, 7, 3540-3553.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top