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Toxins 2015, 7(1), 156-169; doi:10.3390/toxins7010156

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

1
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
2
Center for Protein Science and Crystallography, School of Life Sciences, the Chinese University of Hong Kong, Shatin N.T. 999077, Hong Kong, China
3
Division of HIV/AIDS and STI Control, Yuxi Centers for Disease Control and Prevention, Yuxi 653100, Yunnan, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Nicholas Mantis
Received: 18 September 2014 / Revised: 24 December 2014 / Accepted: 5 January 2015 / Published: 19 January 2015
(This article belongs to the Special Issue Plant Toxins)
View Full-Text   |   Download PDF [844 KB, uploaded 19 January 2015]   |  

Abstract

Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions. View Full-Text
Keywords: maize RIP; anti-HIV; animal model; viral load maize RIP; anti-HIV; animal model; viral load
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Wang, R.-R.; Au, K.-Y.; Zheng, H.-Y.; Gao, L.-M.; Zhang, X.; Luo, R.-H.; Law, S.K.-Y.; Mak, A.N.-S.; Wong, K.-B.; Zhang, M.-X.; Pang, W.; Zhang, G.-H.; Shaw, P.-C.; Zheng, Y.-T. The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques. Toxins 2015, 7, 156-169.

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