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Toxins 2014, 6(10), 2998-3004; doi:10.3390/toxins6102998

Efficacy of Active Carbon towards the Absorption of Deoxynivalenol in Pigs

1
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
2
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
*
Author to whom correspondence should be addressed.
Received: 29 August 2014 / Revised: 14 October 2014 / Accepted: 15 October 2014 / Published: 21 October 2014
(This article belongs to the Special Issue Detoxification of Mycotoxins)
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Abstract

In order to assess the in vivo efficacy of mycotoxin binders, specific toxicokinetic parameters should be measured according to European guidelines. For this purpose, an absorption model in pigs is described with emphasis on absorption kinetics. Pigs received a single oral bolus of the mycotoxin deoxynivalenol alone or in combination with active carbon (applied as mycotoxin binder). After administration of deoxynivalenol alone, significant plasma amounts of deoxynivalenol were detected and kinetic parameters were calculated using a one compartmental model. Activated carbon completely prevented the absorption of deoxynivalenol as no plasma amounts could be detected. View Full-Text
Keywords: deoxynivalenol; absorption model; pig; mycotoxin binder; efficacy testing deoxynivalenol; absorption model; pig; mycotoxin binder; efficacy testing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Devreese, M.; Antonissen, G.; De Backer, P.; Croubels, S. Efficacy of Active Carbon towards the Absorption of Deoxynivalenol in Pigs. Toxins 2014, 6, 2998-3004.

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