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Towards Systems Biology of Mycotoxin Regulation
Eastern Cereal & Oilseed Research Centre, Agriculture & Agri-Food Canada, Ottawa, ON K1A 0C6, Canada
Cereal Research Centre, Agriculture & Agri-Food Canada, Winnipeg, MB R3T 2M9, Canada
* Author to whom correspondence should be addressed.
Received: 25 February 2013; in revised form: 22 March 2013 / Accepted: 10 April 2013 / Published: 18 April 2013
Abstract: Systems biology is a scientific approach that integrates many scientific disciplines to develop a comprehensive understanding of biological phenomena, thus allowing the prediction and accurate simulation of complex biological behaviors. It may be presumptuous to write about toxin regulation at the level of systems biology, but the last decade of research is leading us closer than ever to this approach. Past research has delineated multiple levels of regulation in the pathways leading to the biosynthesis of secondary metabolites, including mycotoxins. At the top of this hierarchy, the global or master transcriptional regulators perceive various environmental cues such as climatic conditions, the availability of nutrients, and the developmental stages of the organism. Information accumulated from various inputs is integrated through a complex web of signalling networks to generate the eventual outcome. This review will focus on adapting techniques such as chemical and other genetic tools available in the model system Saccharomyces cerevisiae, to disentangle the various biological networks involved in the biosynthesis of mycotoxins in the Fusarium spp.
Keywords: synthetic genetic array; Saccharomyces cerevisiae; mycotoxin; chemical genetics
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Subramaniam, R.; Rampitsch, C. Towards Systems Biology of Mycotoxin Regulation. Toxins 2013, 5, 675-682.
Subramaniam R, Rampitsch C. Towards Systems Biology of Mycotoxin Regulation. Toxins. 2013; 5(4):675-682.
Subramaniam, Rajagopal; Rampitsch, Christof. 2013. "Towards Systems Biology of Mycotoxin Regulation." Toxins 5, no. 4: 675-682.