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Toxins 2013, 5(4), 683-702; doi:10.3390/toxins5040683
Review

Oxidative Stress-Related Transcription Factors in the Regulation of Secondary Metabolism

1,†
, 1,†
 and 1,2,3,4,*
Received: 5 March 2013; in revised form: 1 April 2013 / Accepted: 9 April 2013 / Published: 18 April 2013
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Abstract: There is extensive and unequivocal evidence that secondary metabolism in filamentous fungi and plants is associated with oxidative stress. In support of this idea, transcription factors related to oxidative stress response in yeast, plants, and fungi have been shown to participate in controlling secondary metabolism. Aflatoxin biosynthesis, one model of secondary metabolism, has been demonstrated to be triggered and intensified by reactive oxygen species buildup. An oxidative stress-related bZIP transcription factor AtfB is a key player in coordinate expression of antioxidant genes and genes involved in aflatoxin biosynthesis. Recent findings from our laboratory provide strong support for a regulatory network comprised of at least four transcription factors that bind in a highly coordinated and timely manner to promoters of the target genes and regulate their expression. In this review, we will focus on transcription factors involved in co-regulation of aflatoxin biosynthesis with oxidative stress response in aspergilli, and we will discuss the relationship of known oxidative stress-associated transcription factors and secondary metabolism in other organisms. We will also talk about transcription factors that are involved in oxidative stress response, but have not yet been demonstrated to be affiliated with secondary metabolism. The data support the notion that secondary metabolism provides a secondary line of defense in cellular response to oxidative stress.
Keywords: aflatoxin; aspergilli; oxidative stress; secondary metabolism; stress activated signaling pathway; transcription factor aflatoxin; aspergilli; oxidative stress; secondary metabolism; stress activated signaling pathway; transcription factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hong, S.-Y.; Roze, L.V.; Linz, J.E. Oxidative Stress-Related Transcription Factors in the Regulation of Secondary Metabolism. Toxins 2013, 5, 683-702.

AMA Style

Hong S-Y, Roze LV, Linz JE. Oxidative Stress-Related Transcription Factors in the Regulation of Secondary Metabolism. Toxins. 2013; 5(4):683-702.

Chicago/Turabian Style

Hong, Sung-Yong; Roze, Ludmila V.; Linz, John E. 2013. "Oxidative Stress-Related Transcription Factors in the Regulation of Secondary Metabolism." Toxins 5, no. 4: 683-702.



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