Imaging of Convection Enhanced Delivery of Toxins in Humans
Abstract
:1. Introduction
2. In Vivo Imaging of CED Infusate Distribution
3. Albumin-Conjugated Surrogate Tracers
4. MRI Imaging T2 Imaging Changes
5. Gadolinium-Based Liposome Constructs
6. Gadolinium-Bound Albumin
7. Gadolinium Direct Infusion
8. Conclusions
References
- Kanu, O.O.; Mehta, A.; Di, C.; Lin, N.; Borton, K.; Bigner, D.D.; Yan, H.; Adamson, D.C. Glioblastoma multiforme: A review of therapeutic targets. Expert Opin. Ther. Targets 2009, 13, 701–718. [Google Scholar]
- Muldoon, L.L.; Soussain, C.; Jahunke, K.; Johanson, C.; Siegal, T.; Smith, Q.R.; Hall, W.A.; Hynynen, K.; Senter, P.D.; Peereboom, D.M.; Neuwelt, E.A. Chemotherapy delivery issues in central nervous system malignancy: A reality check. J. Clin. Oncol. 2007, 25, 2295–2305. [Google Scholar]
- Bobo, R.H.; Lask, D.W.; Asbasak, A.; Morrison, P.F.; Dedrick, R.L.; Oldfield, E.H. Convection-enhanced delivery of macromolecules in the brain. Proc. Nat. Acad. Sci. USA 1994, 91, 2076–2080. [Google Scholar]
- Ding, D.; Kanaly, C.W.; Bigner, D.D.; Cummings, T.J.; Herndon, J.E.; Pastan, I.; Raghavan, R.; Sampson, J.H. Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. J. Neurooncol. 2010, 98, 1–7. [Google Scholar]
- Sampson, J.H.; Archer, G.; Pedain, C.; Wembacher-Schröder, E.; Westphal, M.; Kunwar, S.; Vogelbaum, M.A.; Coan, A.; Herndon, J.E., II; Raghavan, R.; et al. Poor drug distribution as a possible explanation for the results of the precise trial. J. Neurosurg. 2010, 113, 301–309. [Google Scholar] [CrossRef] [PubMed]
- Sampson, J.H.; Brady, M.L.; Petry, M.A.; Croteau, D.; Friedman, A.H.; Friedman, H.S.; Wong, T.; Bigner, D.D.; Pastan, I.; Puri, R.K.; Pedain, C. Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: Descriptive effects of target anatomy and catheter positioning. Neurosurgery 2007, 60, 89–99. [Google Scholar]
- Sampson, J.H.; Raghavan, R.; Provenzale, J.M.; Croteau, D.; Reardon, D.A.; Coleman, R.E.; Rodriguez-Ponce, I.; Pastan, I.; Puri, R.K.; Pedain, C. Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. AJR Am. J. Roentgenol. 2007, 188, 703–709. [Google Scholar]
- Mardor, Y.; Rahav, O.; Zauberman, Y.; Lidar, Z.; Ocherashvilli, A.; Daniels, D.; Roth, Y.; Maier, S.E.; Orenstein, A.; Ram, Z. Convection-enhanced drug delivery: Increased efficacy and magnetic resonance image monitoring. Cancer Res. 2005, 65, 6858–6863. [Google Scholar]
- Raghavan, R.; Brady, M.L.; Rodriguez-Ponce, M.I.; Hartlep, A.; Pedain, C.; Sampson, J.H. Convection-enhanced delivery of therapeutics for brain disease, and its optimization. Neurosurg. Focus 2006, 20, E12. [Google Scholar]
- Nguyen, T.T.; Pannu, Y.S.; Sung, C.; Dedrick, R.K.; Walbridge, S.; Brechbiel, M.W.; Garmestani, K.; Beitzel, M.; Yordanov, A.T.; Oldfield, E.H. Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonanceimaging. J. Neurosurg. 2003, 98, 584–590. [Google Scholar]
- Dalrymple, L.S.; Koepsell, T.; Sampson, J.; Louie, T.; Dominitz, J.A.; Young, B.; Kestenbaum, B. Hepatitis C virus infection and the prevalence of renal insufficiency. Clin. J. Am. Soc. Nephrol. 2007, 2, 715–721. [Google Scholar]
- Jackson, M.T.; Sampson, J.; Prichard, H.M. Platinum and palladium variations through the urban environment: Evidence from 11 sample types from Sheffield, UK. Sci. Total Environ. 2007, 385, 117–131. [Google Scholar]
- Saito, R.; Bringas, J.R.; McKnight, T.R.; Wendland, M.F.; Mamot, C.; Drummond, D.C.; Kirpotin, D.B.; Park, J.W.; Berger, M.S.; Bankiewicz, K.S. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res. 2004, 64, 2572–2579. [Google Scholar]
- Lonser, R.R.; Walbridge, S.; Murray, G.J.; Aizenberg, M.R.; Vortmeyer, A.O.; Aerts, J.M.; Brady, R.O.; Oldfield, E.H. Convection perfusion of glucocerebrosidase for neuronopathic Gaucher’s disease. Ann. Neurol. 2005, 57, 542–548. [Google Scholar]
- Lonser, R.R.; Schiffman, R.; Robison, R.A.; Butman, J.A.; Quezado, Z.; Walker, M.L.; Morrison, P.F.; Walbridge, S.; Murray, G.J.; Park, D.M.; Brady, R.O.; Oldfield, E.H. Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease. Neurology 2007, 68, 254–261. [Google Scholar]
- Lonser, R.R.; Warren, K.E.; Butman, J.A.; Quezado, Z.; Robison, R.A.; Walbridge, S.; Schiffman, R.; Merrill, M.; Walker, M.L.; Park, D.M.; Croteau, D.; Brady, R.O.; Oldfield, E.H. Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note. J. Neurosurg. 2007, 107, 190–197. [Google Scholar]
- Jagannathan, J.; Walbridge, S.; Butman, J.A.; Oldfield, E.H.; Lonser, R.R. Effect of ependymal and pial surfaces on convection-enhanced delivery. J. Neurosurg. 2008, 109, 547–552. [Google Scholar]
- Szerlip, N.J.; Walbridge, S.; Yang, L.; Morrison, P.F.; Degen, J.W.; Jarrell, S.T.; Kouri, J.; Kerr, P.B.; Kotin, R.; Oldfield, E.H.; Lonser, R.R. Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. J. Neurosurg. 2007, 107, 560–567. [Google Scholar]
- Sampson, J.H.; Raghavan, R.; Mehta, A.I.; Friedman, A.H.; Reardon, D.A.; Petry, N.A.; Barboriak, D.P.; Wong, T.Z.; Zalutsky, M.R.; Lally-Goss, D.; Bigner, D.D. Co-localization of gadolinium-DTPA with high molecular weight molecules after intracerebral convection-enhanced delivery in man. Neurosurgery 2011, in press. [Google Scholar]
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Mehta, A.I.; Choi, B.D.; Raghavan, R.; Brady, M.; Friedman, A.H.; Bigner, D.D.; Pastan, I.; Sampson, J.H. Imaging of Convection Enhanced Delivery of Toxins in Humans. Toxins 2011, 3, 201-206. https://doi.org/10.3390/toxins3030201
Mehta AI, Choi BD, Raghavan R, Brady M, Friedman AH, Bigner DD, Pastan I, Sampson JH. Imaging of Convection Enhanced Delivery of Toxins in Humans. Toxins. 2011; 3(3):201-206. https://doi.org/10.3390/toxins3030201
Chicago/Turabian StyleMehta, Ankit I., Bryan D. Choi, Raghu Raghavan, Martin Brady, Allan H. Friedman, Darell D. Bigner, Ira Pastan, and John H. Sampson. 2011. "Imaging of Convection Enhanced Delivery of Toxins in Humans" Toxins 3, no. 3: 201-206. https://doi.org/10.3390/toxins3030201