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Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi
Department of Biological Sciences, Lincoln Hwy. 1425W., Montgomery Hall, Northern Illinois University, DeKalb, IL 60115, USA
Food and Feed Safety Research Unit USDA, ARS, Southern Regional Research Center, 1100 Robert E. Lee Blvd, New Orleans, LA 70124, USA
* Author to whom correspondence should be addressed.
Received: 19 February 2010; in revised form: 16 March 2010 / Accepted: 17 March 2010 / Published: 24 March 2010
Abstract: Environmental stimuli trigger an adaptative cellular response to optimize the probability of survival and proliferation. In eukaryotic organisms from mammals to fungi osmotic stress, mainly through the action of the high osmolarity glycerol (HOG) pathway, leads to a response necessary for adapting and surviving hyperosmotic environments. In this review we show that the osmoadaptative response is conserved but not identical in different fungi. The osmoadaptative response system is also intimately linked to morphogenesis in filamentous fungi, including mycotoxin producers. Previous studies indicate that the response to osmotic stress is also coupled to the biosynthesis of natural products, including mycotoxins.
Keywords: Aspergillus; osmotic stress; regulation; morphogenesis; secondary metabolism
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Duran, R.; Cary, J.W.; Calvo, A.M. Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi. Toxins 2010, 2, 367-381.
Duran R, Cary JW, Calvo AM. Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi. Toxins. 2010; 2(4):367-381.
Duran, Rocio; Cary, Jeffrey W.; Calvo, Ana M. 2010. "Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi." Toxins 2, no. 4: 367-381.