Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack
AbstractRibosome-inactivating proteins (RIPs) are EC126.96.36.199 N-glycosidases that recognize a universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single adenine (A4324 in rat) and irreversibly blocking protein translation, leading finally to cell death of intoxicated mammalian cells. Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow cell surface binding and toxin entry in most mammalian cells, shows a potency in the picomolar range. The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. Here, we will provide a comprehensive picture of plant RIPs and discuss successful designs and features of chimeric molecules having therapeutic potential. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Virgilio, M.; Lombardi, A.; Caliandro, R.; Fabbrini, M.S. Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack. Toxins 2010, 2, 2699-2737.
Virgilio M, Lombardi A, Caliandro R, Fabbrini MS. Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack. Toxins. 2010; 2(11):2699-2737.Chicago/Turabian Style
Virgilio, Maddalena de; Lombardi, Alessio; Caliandro, Rocco; Fabbrini, Maria Serena. 2010. "Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack." Toxins 2, no. 11: 2699-2737.