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Tetanus Toxin C-Fragment: The Courier and the Cure?
LAGENBIO-I3A, Veterinary School, Aragón Institute of Health Sciences (IACS), Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
* Author to whom correspondence should be addressed.
Received: 11 October 2010; Accepted: 28 October 2010 / Published: 29 October 2010
Abstract: In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic C‑fragment of tetanus toxin (TTC), provided either as protein or encoded by non-viral naked DNA plasmid, binds pre-synaptic motor neuron terminals and can facilitate the retrograde axonal transport of desired therapeutic molecules to the CNS. Alleviated symptoms in animal models of neurological diseases upon delivery of therapeutic molecules offer a hopeful prospect for TTC therapy. This review focuses on what has been learned on TTC-mediated neuronal targeting, and discusses the recent discovery that, instead of being merely a carrier molecule, TTC itself may well harbor neuroprotective properties.
Keywords: tetanus toxin C-fragment; therapeutic molecules; gene therapy; retrograde transport; neurodegenerative disease; motor neuron disease
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Toivonen, J.M.; Oliván, S.; Osta, R. Tetanus Toxin C-Fragment: The Courier and the Cure? Toxins 2010, 2, 2622-2644.
Toivonen JM, Oliván S, Osta R. Tetanus Toxin C-Fragment: The Courier and the Cure? Toxins. 2010; 2(11):2622-2644.
Toivonen, Janne M.; Oliván, Sara; Osta, Rosario. 2010. "Tetanus Toxin C-Fragment: The Courier and the Cure?" Toxins 2, no. 11: 2622-2644.