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Snake Venom Disintegrins and Cell Migration
Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP, 13565-905, Brazil
* Author to whom correspondence should be addressed.
Received: 24 August 2010; in revised form: 15 October 2010 / Accepted: 18 October 2010 / Published: 29 October 2010
Abstract: Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement. Among these receptors are the integrins, which connect the cell cytoskeleton to the extracellular matrix components, thus playing a central role in cell migration. Integrin clustering at focal adhesions drives actin polymerization along the cell leading edge, resulting in polarity of cell movement. Therefore, small integrin-binding proteins such as the snake venom disintegrins that inhibit integrin-mediated cell adhesion are expected to inhibit cell migration. Here we review the current knowledge on disintegrin and disintegrin-like protein effects on cell migration and their potential use as pharmacological tools in anti-inflammatory therapy as well as in inhibition of metastatic invasion.
Keywords: cell migration; disintegrin; snake venom; ADAM; αvβ3 integrin
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Selistre-de-Araujo, H.S.; Pontes, C.L.S.; Montenegro, C.F.; Martin, A.C.B.M. Snake Venom Disintegrins and Cell Migration. Toxins 2010, 2, 2606-2621.
Selistre-de-Araujo HS, Pontes CLS, Montenegro CF, Martin ACBM. Snake Venom Disintegrins and Cell Migration. Toxins. 2010; 2(11):2606-2621.
Selistre-de-Araujo, Heloisa S.; Pontes, Carmen L. S.; Montenegro, Cyntia F.; Martin, Ana Carolina B. M. 2010. "Snake Venom Disintegrins and Cell Migration." Toxins 2, no. 11: 2606-2621.