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Toxins 2010, 2(1), 10-23; doi:10.3390/toxins2010010
Review

Structure and Function of Snake Venom Proteins Affecting Platelet Plug Formation

1,* , 2
 and 3
Received: 1 December 2009; in revised form: 18 December 2009 / Accepted: 24 December 2009 / Published: 28 December 2009
(This article belongs to the Special Issue Animal Venoms)
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Abstract: Many snake venom proteins have been isolated that affect platelet plug formation by interacting either with platelet integrins, membrane glycoprotein Ib (GPIb), or plasma von Willebrand factor (VWF). Among them, disintegrins purified from various snake venoms are strong inhibitors of platelet aggregation. Botrocetin and bitiscetin derived from Bothrops jararaca and Bitis arietans venom, respectively, induce VWF-dependent platelet agglutination in vitro. Several GPIb-binding proteins have also been isolated from snake venoms. In this review, we focus on the structure and function of those snake venom proteins that influence platelet plug formation. These proteins are potentially useful as reagents for the sub-diagnosis of platelet disorder or von Willebrand disease, as well as for clinical and basic research of thrombosis and hemostasis.
Keywords: disintegrin; snake venom; von Willebrand factor; platelet GPIb; thrombosis disintegrin; snake venom; von Willebrand factor; platelet GPIb; thrombosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Matsui, T.; Hamako, J.; Titani, K. Structure and Function of Snake Venom Proteins Affecting Platelet Plug Formation. Toxins 2010, 2, 10-23.

AMA Style

Matsui T, Hamako J, Titani K. Structure and Function of Snake Venom Proteins Affecting Platelet Plug Formation. Toxins. 2010; 2(1):10-23.

Chicago/Turabian Style

Matsui, Taei; Hamako, Jiharu; Titani, Koiti. 2010. "Structure and Function of Snake Venom Proteins Affecting Platelet Plug Formation." Toxins 2, no. 1: 10-23.


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