Next Article in Journal
The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity
Next Article in Special Issue
Animal Toxins: How is Complexity Represented in Databases?
Previous Article in Journal
Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment
Previous Article in Special Issue
Structure and Function of Snake Venom Proteins Affecting Platelet Plug Formation
Toxins 2010, 2(1), 163-173; doi:10.3390/toxins2010163
Review

Bothrops lanceolatus Bites: Guidelines for Severity Assessment and Emergent Management

1,2,* , 3, 1, 1 and 1
Received: 6 December 2009; in revised form: 13 January 2010 / Accepted: 19 January 2010 / Published: 22 January 2010
(This article belongs to the Special Issue Animal Venoms)
View Full-Text   |   Download PDF [370 KB, uploaded 22 January 2010]   |   Browse Figures
Abstract: Approximately 20–30 declared snakebite cases occurin Martinique each year. Bothrops lanceolatus, a member of the Crotalidae family, is considered to be the only involved snake. B. lanceolatus, commonly named “Fer-de-Lance”, is endemic and only found on this Caribbean island. Envenomation local features include the presence of fang marks, swelling, pain, bleeding from punctures, and ecchymosis. Severe envenomation is associated with multiple systemic thromboses appearing within 48 h of the bite and resulting in cerebral, myocardial or pulmonary infarctions. Diagnosis requires first of all identification of the snake. Coagulation tests are helpful to identify thrombocytopenia or disseminated intravascular coagulation. A clinical score based on 4 grades is helpful to assess envonimation severity. A specific monovalent equine anti-venom (Bothrofav®, Sanofi-Pasteur, France) to neutralize B. lanceolatus venom is available. Its early administration within 6h from the biting in case of progressive local injures, general signs or coagulation disturbances is effective to prevent severe thrombosis and coagulopathy. Its tolerance is considered to be good. Despite an increasing incidence of bites, no deaths have been recently attributed to B. lanceolatus in Martinique, probably due to the currently recommended strategy of early antivenom administration when required.
Keywords: Bothrops lanceolatus; Martinique; snake bite; severity; coaguloapthy; antivenom serum Bothrops lanceolatus; Martinique; snake bite; severity; coaguloapthy; antivenom serum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Resiere, D.; Mégarbane, B.; Valentino, R.; Mehdaoui, H.; Thomas, L. Bothrops lanceolatus Bites: Guidelines for Severity Assessment and Emergent Management. Toxins 2010, 2, 163-173.

AMA Style

Resiere D, Mégarbane B, Valentino R, Mehdaoui H, Thomas L. Bothrops lanceolatus Bites: Guidelines for Severity Assessment and Emergent Management. Toxins. 2010; 2(1):163-173.

Chicago/Turabian Style

Resiere, Dabor; Mégarbane, Bruno; Valentino, Ruddy; Mehdaoui, Hossein; Thomas, Laurent. 2010. "Bothrops lanceolatus Bites: Guidelines for Severity Assessment and Emergent Management." Toxins 2, no. 1: 163-173.


Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert