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Toxins 2018, 10(3), 112; https://doi.org/10.3390/toxins10030112

Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
These authors contributed equally to this work.
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Received: 29 January 2018 / Revised: 2 March 2018 / Accepted: 3 March 2018 / Published: 7 March 2018
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Abstract

Cytochrome P450s (CYPs), heme-containing monooxygenases, play important roles in a wide variety of metabolic processes important for development as well as biotic/trophic interactions in most living organisms. Functions of some CYP enzymes are similar across organisms, but some are organism-specific; they are involved in the biosynthesis of structural components, signaling networks, secondary metabolisms, and xenobiotic/drug detoxification. Fungi possess more diverse CYP families than plants, animals, or bacteria. Various fungal CYPs are involved in not only ergosterol synthesis and virulence but also in the production of a wide array of secondary metabolites, which exert toxic effects on humans and other animals. Although few studies have investigated the functions of fungal CYPs, a recent systematic functional analysis of CYP genes in the plant pathogen Fusarium graminearum identified several novel CYPs specifically involved in virulence, asexual and sexual development, and degradation of xenobiotics. This review provides fundamental information on fungal CYPs and a new platform for further metabolomic and biochemical studies of CYPs in toxigenic fungi. View Full-Text
Keywords: cytochrome P450; secondary metabolism; xenobiotics; Fusarium graminearum cytochrome P450; secondary metabolism; xenobiotics; Fusarium graminearum
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Shin, J.; Kim, J.-E.; Lee, Y.-W.; Son, H. Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum. Toxins 2018, 10, 112.

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